女性性激素的特别用途

黄体酮，又称孕酮，一种女性性激素。《美国科学院院刊》在一月份的时候报导过：女性月经周期的性激素水平能够影响大脑奖励环路的敏感度。这也许有助于人们深入了解与月经有关的情绪变化，研究显示女性在前排卵期（月经结束后四至八天）比在后排卵期更期望奖励。除此之外，美国科学家还发现一种特殊用途，这种女性性激素也许能够治疗脑外伤（TBI），并且没有副作用。-psytopic.com


（健康日报新闻）――美国科学家称，黄体酮，又称孕酮，一种女性性激素，也许能够治疗脑外伤（TBI）。

“我们发现了令人鼓舞的证据，黄体酮在脑外伤恢复方面是安全的，同时没有发现副作用或者是严重伤害事件方面的证据，” 亚特兰大依莫瑞（Emory）大学保健科学中心的紧急医疗部的副教授，研究作者David Wright，在事先准备好的报告中说。

他的团队对100名由于高中堕物，汽车或者摩托车相撞事故中钝器所至的脑外伤患者进行了两组研究。

大约有13%的接受静脉注射黄体酮的TBI患者在30天之内死亡，而接受安慰剂治疗的高达30%。大部分死者都是死于严重的TBI。

这项发现已经发表于《紧急医疗年报》10月成果在线版。

“另外，我们发现接受黄体酮治疗的一组死亡率降低了50%。而且，我们发现在那些登记为中等程度脑外伤的患者中，在功能性结果以及残疾水平都有显著改善。”Wright说。

研究的下一步是要在更大的脑外伤患者群体中来确认这一发现。

我们都知道，女性的“性类固醇”，黄体酮同时也是让大脑神经元正常发展的一种重要的神经类固醇，并且尽力发挥对受伤大脑的保护效应。研究者写道。

黄体酮是在男性与女性大脑中自然分泌的。



原文阅读：Female Sex Hormone Could Treat Brain Injury


(HealthDay News) -- Progesterone, a female sex hormone, may help treat traumatic brain injury (TBI), U.S. scientists report.

"We found encouraging evidence that progesterone is safe in the setting of TBI, with no evidence of side effects or serious harmful events," study author Dr. David Wright, an assistant professor in the department of emergency medicine at Emory University Health Sciences Center in Atlanta, said in a prepared statement.

His team conducted a phase II study of 100 patients with blunt TBI, which typically occurs in falls or in car and motorcycle crashes.

About 13 percent of TBI patients who received intravenous progesterone died within 30 days, compared to about 30 percent of patients who received a placebo. Most of the patients who died had severe TBI.

The findings were published online in the October issue of the Annals of Emergency Medicine.

"In addition, we found a 50 percent reduction in the rate of death in the progesterone-treated group. Furthermore, we found a significant improvement in the functional outcome and level of disability among patients who were enrolled with a moderate brain injury," Wright said.

The next step in this research is to confirm the findings of this study in a much larger group of TBI patients.

Widely known as a female "sex steroid," progesterone is also a neurosteroid that's critical for the normal development of neurons in the brain and "exerts protective effects on damaged brain tissue," the researchers wrote. Progesterone is naturally present in the brains of females and males.



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